Transcriptomics in Rare Minnow (Gobiocypris rarus) towards Attenuated and Virulent Grass Carp Reovirus Genotype II Infection

Grass carp reovirus genotype Ⅱ (GCRV Ⅱ) causes a variety of fish hemorrhagic disease, which seriously affects the sustainable development grass aquaculture in China. Rare minnow (Gobiocypris rarus) is an ideal model to study pathogenesis GCRV Ⅱ. To investigate involved molecular responses against infection, we performed comparative transcriptomic analysis spleen and liver rare injected with virulent strain DY197 attenuated QJ205. Results showed that induced more differently expressed genes (DEGs) than QJ205 strain, tissue-specific were induced. In spleen, strains different DEGs; infection activated steroid synthesis pathway membrane formation; however, innate immunity apoptosis related pathways while suppressing cell proliferation migration are important for damage tissue repair, as well hemorrhage pathways. liver, similar both but suppressed metabolism-related pathways; especially protein digestion absorption-related pathway. conclude, alterations caused severe suppression hemorrhage-related spleen. Our findings will contribute better understanding interactions between host II.